Mostly improves, sometimes worsens, rarely emerges. We watch carefully.
What typically happens
Most patients report improved mood with weight loss — increased confidence, better sleep, more energy.
Be alert for
Worsening of pre-existing depression, new low mood with no obvious trigger, loss of interest in activities. Even mild — report early.
Suicidal ideation
Rare on GLP-1 medications, but we screen carefully because the FDA has flagged a small signal under review. If thoughts of self-harm emerge, stop the medication and seek immediate help.
