Thyroid disease and GLP-1

Hypothyroidism is common in India. It interacts with weight in specific ways — and with GLP-1.

Untreated hypothyroidism

Causes weight gain, fatigue, slow metabolism. Treating it is the first step — GLP-1 on top of untreated hypothyroidism is suboptimal.

Treated hypothyroidism + GLP-1

Compatible. Take levothyroxine on empty stomach, 30 min before food (no different from before). Recheck TSH every 6 months — sometimes weight loss requires a small dose adjustment.

Hyperthyroidism

Less common but matters. Untreated hyper- shouldn't start GLP-1 until thyroid is stabilised.